Guillan-Barre syndrome triggered by heat stroke: clinical case and literature review

Authors

  • Juan Carlos López-Hernández Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
  • Lilia Salas Alvarado Intituto Nacional de Neurología y Neurocirugía
  • Victoria Martínez Angeles Intituto Nacional de Neurología y Neurocirugía
  • Elma Paredes Aragon Intituto Nacional de Neurología y Neurocirugía
  • Edwin Steven Vargas Cañas Instituto Nacional de Neurología y Neurocirugía

Keywords:

Guillain-Barré syndrome, heat stroke, Case Report

Abstract

Introduction: Guillain-Barre syndrome is triggered in 70% of cases by some infectious agent. Heat stroke favors a pro-inflammatory state and endotoxemia at the gastrointestinal level. Few clinical cases of GBS following heat stroke are reported.

Objective: to report a clinical case of a patient who presented GBS after heat stroke.

Material and methods: clinical case report

Result: a 31-year-old male patient in agricultural occupation, presented heat stroke due to exertion while working (temperature 40ºC, epileptic seizures and drowsiness), requiring invasive mechanical ventilation, control of hyperthermia with physical means; presents good evolution, recovering and being discharged at home. On the day of his discharge, he presented symptoms of distal paresthesia and weakness in the 4 extremities ascending until he could not ambulate. In the examination without involvement of skull nerves, areflexia, strength in extremities with MRC score 28 points. Lumbar puncture with protein-cytological dissociation, nerve conduction compatible with AMSAN variant. He was diagnosed with GBS (level 1 of diagnostic certainty by Brighton criteria) after heat stroke, received management with human immunoglobulin, at 3 months of follow-up he recovered his independent gait.

Conclusion: Heat stroke is a potentially fatal condition, triggering a systemic pro-inflammatory state and endotoxemia at the gastrointestinal level, conditions that can facilitate the presentation of autoimmune inflammatory diseases such as Guillaín-Barre syndrome. More studies are required to establish the pathophysiology of GBS after heat stroke.

References

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Additional Files

Published

2023-08-03

How to Cite

López-Hernández, J. C. ., Salas Alvarado, L., Martínez Angeles, V., Paredes Aragon, E., & Vargas Cañas, E. S. (2023). Guillan-Barre syndrome triggered by heat stroke: clinical case and literature review. Archivos De Neurociencias, 1(Inpress). Retrieved from https://archivosdeneurociencias.org/index.php/ADN/article/view/517

Issue

Articles in press

Section

Case report

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Copyright (c) 2022 Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez

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September 2022-present © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Open access articles under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. No commercial re-use is allowed.

January-September 2022 © The authors. Open access articles under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. No commercial re-use is allowed.

January 2014-December 2021 © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Open access articles under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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