Metabolism and effect of dehydroepiandrosterone (DHEA) in the central nervous system

Authors

  • Miguel Ángel Márquez-Flores Departamento de Neuroquímica. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
  • Hugo Sandoval Unidad de Investigación Sociomédica. Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
  • Iván Pérez-Neri Departamento de Neuroquímica. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
  • Camilo Ríos Departamento de Neuroquímica. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
  • Carlos Eduardo Diéguez-Campa Instituto de Ciencias Biomédicas. Universidad Autónoma de Ciudad Juárez. Chihuahua, Méxic

DOI:

https://doi.org/10.31157/an.v25i3.248

Keywords:

Dehydroepiandrosterone, enzymes, central nervous system

Abstract

Dehydroepiandrosterone (DHEA) is not only an active steroid, but it also leads to non-genomic effects. More findings on steroid synthesis in the central nervous system (CNS) have been reported showing that the differences with endocrine organs are minimal. Maybe the explanation of the multiple effects of a single molecule as DHEA lies in those pathways. In the CNS, those actions include neuroprotection, dendrite growth, apoptosis, catecholamine synthesis and secretion, as well as antioxidant, anti-inflammatory, and anti-glucocorticoid functions. Changes in DHEA serum concentration are associated with several diseases. This concentration decreases with age from its maximum in the young people to its minimum when some aging-related disorders are increasingly prevalent. Both DHEA and other steroids generate some effects, but they may also be metabolized to other active molecules, increasing the complexity of their effect; thus, it is essential to describe those metabolic interactions to understand the findings regarding these messengers better.

Published

2020-10-14

How to Cite

Márquez-Flores , M. Ángel, Sandoval , H., Pérez-Neri, I., Ríos, C., & Diéguez-Campa , C. E. (2020). Metabolism and effect of dehydroepiandrosterone (DHEA) in the central nervous system. Archivos De Neurociencias, 25(3), 51–58. https://doi.org/10.31157/an.v25i3.248

Issue

Section

Evidence synthesis

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