Advances in preclinical research of the C-Terminal domain of the heavy chain of the tetanic toxin in neurodegenerative diseases

Authors

  • Irving Parra
  • Isabel Martínez
  • Félix Luna
  • Victorino Alatriste
  • Daniel Limón
  • Liliana Mendieta

DOI:

https://doi.org/10.31157/an.v25i1.196

Keywords:

HC-TeTx, methamphetamine, neurodegeneration, neuroprotection, parkinson’s desease

Abstract

Tetanus toxin is a polypeptide of 1315 aminoacids of 150 kDa, from which a non-toxic fraction of 50 kDa is extracted that has the ability to cross the blood brain barrier through mechanisms that full-length toxin, have developed to throughout its evolution. We refer to axonal retrograde trip and synaptic jumps. Studies indicate that the C-terminal domain of the tetanus toxin heavy chain, in vivo and in vitro, has neuromodulatory, neuroprotective and antiapoptotic properties when confronted with neurotoxic agents such as MPTP, 6-hydroxypamine or methamphetamine. Therefore, there are high expectations about the therapy with HC-TeTx, and its multiple variants, regarding the neuroprotection they provide. With all before said, we propose that HC has the potential to be a drug with multiple applications. Even with this, questions remain to be resolved and more studies are required to show in detail the aforementioned effects.

Published

2020-03-01

How to Cite

Parra, I., Martínez, I., Luna, F., Alatriste, V., Limón, D., & Liliana Mendieta. (2020). Advances in preclinical research of the C-Terminal domain of the heavy chain of the tetanic toxin in neurodegenerative diseases. Archivos De Neurociencias, 25(1), 61–76. https://doi.org/10.31157/an.v25i1.196

Issue

Section

Evidence synthesis