Mechanisms for brain protection in neuroanesthesia


  • Marcela Amparo Osuna-Zazueta
  • Juan Antonio Ponce-Gómez
  • Iván Pérez-Neri



oxidative stress, excitotoxicity, ischemia, neuroanesthesia


There is currently an intensive search for the mechanisms to protect the central nervous system against hypoxia and ischemia. The main challenge for neuroanesthesiologists is to block the biochemical cascade that follows ischemia, to protect the brain during and after a neurological surgery. The main damaging mechanisms in those pathologies includes the release of cytokines and excitatory amino acids as well as generation of reactive oxygen species, which may be modulated by anesthetic drugs like thiopental and propofol, among others. Additionally, neuroanesthesia allows several interventions to protect the brain as the maintenance of brain blood Flow and volume, oxygen, temperature, vascular resistance and glucose levels. Knowledge of the pathophysiologic mechanisms in ischemia and their modulation in neuroanesthesia may improve prognosis and outcome for patients undergoing a medical intervention involving an anesthetic technique for the treatment of diseases that include brain ischemia.



How to Cite

Osuna-Zazueta, M. A., Ponce-Gómez, J. A., & Pérez-Neri, I. (2014). Mechanisms for brain protection in neuroanesthesia. Archivos De Neurociencias, 19(4), 205–211.



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