Mechanisms for brain protection in neuroanesthesia
DOI:
https://doi.org/10.31157/an.v19i4.62Keywords:
oxidative stress, excitotoxicity, ischemia, neuroanesthesiaAbstract
There is currently an intensive search for the mechanisms to protect the central nervous system against hypoxia and ischemia. The main challenge for neuroanesthesiologists is to block the biochemical cascade that follows ischemia, to protect the brain during and after a neurological surgery. The main damaging mechanisms in those pathologies includes the release of cytokines and excitatory amino acids as well as generation of reactive oxygen species, which may be modulated by anesthetic drugs like thiopental and propofol, among others. Additionally, neuroanesthesia allows several interventions to protect the brain as the maintenance of brain blood Flow and volume, oxygen, temperature, vascular resistance and glucose levels. Knowledge of the pathophysiologic mechanisms in ischemia and their modulation in neuroanesthesia may improve prognosis and outcome for patients undergoing a medical intervention involving an anesthetic technique for the treatment of diseases that include brain ischemia.Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2014 Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez
This work is licensed under a Creative Commons Attribution 4.0 International License.
September 2022-present © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Open access articles under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. No commercial re-use is allowed.
January-September 2022 © The authors. Open access articles under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. No commercial re-use is allowed.
January 2014-December 2021 © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Open access articles under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.