Late onset inflammatory myopathy associated with Anti-Ro52 antibodies without lung involvement: A case report


  • Mitzi Gabriela Márquez Vargas Instituto Nacional de Neurología y Neurocirugía"Manuel Velasco Suárez"
  • Angel Escamilla-Ramírez
  • Gina Gonzalez-Calderón
  • Karen Flores Velez
  • Juan Carlos Lopez-Hernandez
  • Javier Galnares Olalde
  • Edwin Steven Vargas Cañas


Inflammatory myopathies, Dermatomyositis, Anti-Ro52, Systemic neoplasm, Interstitial lung disease


Introduction. Idiopathic inflammatory myopathies are a heterogeneous group of autoinmune diseases. Clinically they are characterized by symmetric muscle weakness and sometimes systemic involvement. They present neurophysiological and histological signs of chronic muscle inflammation, as well as elevation of muscle enzymes. Specific autoantibodies are useful biomarkers for diagnosis. We present the case of a patient with dermatomyositis (DM) and positive anti-Ro52 antibodies without systemic activity at diagnosis.

Clinical case. An 87-year-old woman with a history of basal cell carcinoma in the left malar region and hypothyroidism, both under control. Presented a progressive disease which began 6 months prior to the evaluation by our department, characterized by fatigue, weakness of proximal muscles in the four extremities, associated with myalgia in the pelvic girdle. Over the course of 2 months, showed difficulty performing instrumented activities of daily living. At the fifth month, she manifested dysphagia. On physical examination, symmetric weakness was documented, predominantly proximal, without alteration of the muscle stretch reflexes or sensory involvement. Laboratory analysis showed CK elevation (2974 U/L). A panel of antibodies was made, finding anti Ro52 +++. Body PET revealed hypometabolism in the proximal muscles of the four extremities, with no evidence of neoplastic activity. A muscle biopsy was performed, observing findings compatible with DM. Management began with methylprednisolone pulses, presenting symptomatic improvement.

Discussion and Conclusions: The association of anti-Ro52 antibodies and DM is rare, occurring in up to 26% in overlapping syndromes. The presentation of interstitial lung disease and cáncer have a poor prognosis


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How to Cite

Márquez Vargas, M. G., Escamilla-Ramírez, A., Gonzalez-Calderón, G., Flores Velez, K., Lopez-Hernandez, J. C., Galnares Olalde, J., & Vargas Cañas, E. S. (2023). Late onset inflammatory myopathy associated with Anti-Ro52 antibodies without lung involvement: A case report. Archivos De Neurociencias, 1(Inpress). Retrieved from



Case report

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