Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic upon schizophrenic patients: a systematic review and network meta-analysis


  • Erasmo Sauceo Uribe Departamento de psiquiatria, Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
  • Pedro Jehu Gonzalez Mallozzi
  • Raúl Ricardo Medrano Garza
  • Fernando Diaz Gonzalez Colmenero
  • Farid Carranza Navarro
  • Patricia Lizeth Castillo-Morales
  • Paloma Leyva Camacho
  • Yessica Herrera Montemayor
  • Mauricio Vidal Tijerina
  • Moises Karika Enriquez Navarro
  • Samantha B. Medrano
  • Stefan Mauricio Fernandez Zambrano
  • Claudia Magdalena Mancias Guerra
  • Claudia Lizeth Saucedo Mancias
  • Manuel Ramiro Sanchez Ramirez


schizophrenia, antipsychotics., Long-acting injectable antipsychotics


Introduction: Long-acting injectable antipsychotics (LAIA) can lead the course of treatment with the potential to increase adherence in schizophrenia treatment. The objective of this systematic review and network meta-analysis is to find the efficacy of SG-LAIAs, FG-LAIAs compared to each other for schizophrenia.

Methods: This systematic review and network meta-analysis was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), with registration in Prospero (ID CRD42019128700). A database in MEDLINE, EMBASE, Web of Science, and Scopus, until June 17, 2020, with an actualization from June 2020 to September 14, 2021. 

Results: The SMDs for the four (80%) antipsychotics that significantly reduced PANSS score compared with placebo ranged between –0·72 (95% CrI –0·99 to –0·46) for haloperidol to –0·45 (–0·54 to –0·37) for paliperidone. 8 studies reported usable results for negative symptoms and positive symptoms (Four antipsychotics compared). The SMDs for the three (75%) antipsychotics that significantly reduced negative symptoms compared with placebo ranged between –0·40 (95% CrI –0·53 to –0·26) for aripiprazole to –0·32 (–0·44 to –0·19) for risperidone. The SMDs for the three (100%) drugs that significantly reduced positive symptoms compared with placebo ranged between –0·50 (95% CrI –0·63 to –0·37) for aripiprazole to –0·19 (–0·57 to 0·20) for zuclopenthixol.

Discussion: We found evidence suggesting that all long-acting injectable antipsychotics, except for zuclopenthixol, are equally efficient in reducing symptoms in schizophrenia,

Conclusions: Most LAIAs are equally efficient at reducing overall symptoms, and differences between individual LAIAs are non-significant.


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How to Cite

Sauceo Uribe, E., Gonzalez Mallozzi, P. J., Medrano Garza, R. R., Diaz Gonzalez Colmenero, F., Carranza Navarro, F., Castillo-Morales, P. L., Leyva Camacho, P., Herrera Montemayor, Y., Vidal Tijerina, M., Enriquez Navarro, M. K., Medrano, S. B., Fernandez Zambrano, S. M., Mancias Guerra, C. M., Saucedo Mancias, C. L., & Sanchez Ramirez, M. R. (2023). Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic upon schizophrenic patients: a systematic review and network meta-analysis. Archivos De Neurociencias, 1(Inpress). Retrieved from



Evidence synthesis