Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic upon schizophrenic patients: a systematic review and network meta-analysis

Authors

  • Erasmo Sauceo-Uribe Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Pedro Jehu Gonzalez-Mallozzi Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Raúl Ricardo Medrano-Garza Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico https://orcid.org/0000-0002-0304-6624
  • Fernando Diaz Gonzalez-Colmenero Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Farid Carranza-Navarro Department of Psychiatry, Faculty of Medicine, Universidad Autónoma de Nuevo León
  • Patricia Lizeth Castillo-Morales Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Paloma Leyva-Camacho
  • Yessica Herrera-Montemayor Advanced Neuroscience Center Universidad Autónoma de Nuevo León
  • Mauricio Vidal-Tijerina Department of Psychiatry, Faculty of Medicine, Universidad Autónoma de Nuevo León
  • Moises Karika Enriquez-Navarro Department of Psychiatry, Faculty of Medicine, Universidad Autónoma de Nuevo León
  • Samantha B. Medrano INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autonoma de Nuevo Leon, México.
  • Stefan Mauricio Fernandez-Zambrano Department of Psychiatry, Faculty of Medicine, Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Claudia Magdalena Mancias-Guerra Advanced Neuroscience Center Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Claudia Lizeth Saucedo-Mancias Advanced Neuroscience Center Universidad Autonoma de Nuevo Leon (UANL). Mexico
  • Manuel Ramiro Sanchez-Ramirez Advanced Neuroscience Center Universidad Autonoma de Nuevo Leon (UANL). Mexico.

DOI:

https://doi.org/10.31157/an.v28i2.432

Keywords:

schizophrenia, antipsychotics., Long-acting injectable antipsychotics

Abstract

Introduction: Long-acting injectable antipsychotics (LAIA) can lead the course of treatment with the potential to increase adherence in schizophrenia treatment. The objective of this systematic review and network meta-analysis is to find the efficacy of SG-LAIAs, FG-LAIAs compared to each other for schizophrenia.

Methods: This systematic review and network meta-analysis was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), with registration in Prospero (ID CRD42019128700). A database in MEDLINE, EMBASE, Web of Science, and Scopus, until June 17, 2020, with an actualization from June 2020 to September 14, 2021. 

Results: The SMDs for the four (80%) antipsychotics that significantly reduced PANSS score compared with placebo ranged between –0·72 (95% CrI –0·99 to –0·46) for haloperidol to –0·45 (–0·54 to –0·37) for paliperidone. 8 studies reported usable results for negative symptoms and positive symptoms (Four antipsychotics compared). The SMDs for the three (75%) antipsychotics that significantly reduced negative symptoms compared with placebo ranged between –0·40 (95% CrI –0·53 to –0·26) for aripiprazole to –0·32 (–0·44 to –0·19) for risperidone. The SMDs for the three (100%) drugs that significantly reduced positive symptoms compared with placebo ranged between –0·50 (95% CrI –0·63 to –0·37) for aripiprazole to –0·19 (–0·57 to 0·20) for zuclopenthixol.

Discussion: We found evidence suggesting that all long-acting injectable antipsychotics, except for zuclopenthixol, are equally efficient in reducing symptoms in schizophrenia,

Conclusions: Most LAIAs are equally efficient at reducing overall symptoms, and differences between individual LAIAs are non-significant.

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Additional Files

Published

2023-02-28

How to Cite

Sauceo-Uribe, E., Gonzalez-Mallozzi, P. J., Medrano-Garza, R. R., Diaz Gonzalez-Colmenero, F., Carranza-Navarro, F., Castillo-Morales, P. L., Leyva-Camacho, P., Herrera-Montemayor, Y., Vidal-Tijerina, M., Enriquez-Navarro, M. K., Medrano, S. B., Fernandez-Zambrano, S. M., Mancias-Guerra, C. M., Saucedo-Mancias, C. L., & Sanchez-Ramirez, M. R. (2023). Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic upon schizophrenic patients: a systematic review and network meta-analysis. Archivos De Neurociencias, 28(2). https://doi.org/10.31157/an.v28i2.432

Issue

Section

Evidence synthesis