Evaluation of the antioxidant effect of olanzapine in combination with N Acetyl Cysteine in a mouse model of schizophrenia induced by MK-801.


  • Reyna Lamas-Aguilar Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico.
  • Iván Pérez-Neri Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico. https://orcid.org/0000-0003-0190-7272
  • Camilo Rios Molecular Neuropharmacology Laboratory, Department of Biological Systems, Universidad Autónoma Metropolitana, Xochimilco Unit. Mexico City, Mexico. https://orcid.org/0000-0001-5407-1558
  • Alfonso Mata-Bermúdez Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico https://orcid.org/0000-0002-2234-7019
  • Erick Martínez Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico
  • Norman Manning Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico
  • Araceli Diaz-Ruiz Department of Neurochemistry, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez. Mexico City, Mexico https://orcid.org/0000-0002-1481-0966




Modelo de esquizofrenia; MK-801; Olanzapina, N-acetil Cisteína; Lipoperoxidación; Glutatión Reducido.


Introduction: Schizophrenia is a chronic condition that affects 1% of the population. One of the main theories that explain the etiology of schizophrenia is related to the hypofunction of glutamate N-Methyl-d-Aspartate (NMDA) receptors, inducing the loss of balance between the production of oxidant species produced in the metabolism. cell and antioxidant defense systems, which generates a state of oxidative stress. N-acetylcysteine (NAC) has been proposed as an adjuvant agent to enhance the effectiveness of atypical antipsychotics such as olanzapine, improving the oxidation processes inherent to the disease. Methods: 30 mice divided into 5 experimental groups were used and MK-801 (an NMDA antagonist) was administered as a model of schizophrenia. The participation of oxidative stress was evaluated by measuring lipid peroxidation and reduced glutathione concentration at the level of the frontal cortex. Results: The administration of MK-801 produced an increase in lipid peroxidation and a decrease in the concentration of reduced glutathione at the level of the frontal cortex. In this same sense, both treatment with Olanzapine (OLA) and with NAC and with the combination of OLA-NAC decreased lipid peroxidation and increased glutathione in brain tissue. Discussion: These data suggest that treatment with OLA and NAC could regulate the oxidative damage inherent to the disease and represent a therapeutic option for patients with chronic psychosis or even those resistant to pharmacological treatment.


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How to Cite

Lamas-Aguilar, R., Pérez-Neri, I., Rios, C., Mata-Bermúdez, A., Martínez, E., Manning, N., & Diaz-Ruiz, A. (2022). Evaluation of the antioxidant effect of olanzapine in combination with N Acetyl Cysteine in a mouse model of schizophrenia induced by MK-801. Archivos De Neurociencias, 28(3). https://doi.org/10.31157/an.v28i3.399



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