Temporal lobe epilepsy post-status epilepticus by pilocarpine, and hippocampus-thalamus-cortical connections

Abstract

Temporal lobe epilepsy (TLE) is the most common type of chronic partial epilepsy and refractory to medical treatment in adults. It is a disorder of neuronal excitability, the characteristic of which is that seizure start in any part of the temporal lobe and in which different cellular and molecular processes of different cortical and subcortical neural networks are involved. The objective of this review is to consider several of the general and specific aspects of TLE in humans and to establish possible relationships with the findings obtained mainly the experimental model of post-status epilepticus (SE) rats by pilocarpine in our laboratory, with the information reported in the bibliography. In particular, to analyze several of the different changes that are established in the cellular mechanisms and neural networks in the hippocampus, thalamus, and cerebral cortex. With the extensive research that is carried out about the topic, we have identified various and complex processes that occur in the different brain structures, during the development of epileptogenesis, however, we still have many questions to solve using an experimental model of seizures and the study of epilepsy from the clinical point of view.